Stewardship / Resistance Scan for Feb 20, 2018

first_imgCARB-X announces first award for 2018, two more funding roundsCARB-X, a public-private collaboration that supports companies in early-stage antibiotic discovery and development, recently announced its first funding award for 2018 and provided details about two funding rounds for the current year.CARB-X said in a Feb 15 announcement that it is funding Curza, based in Salt Lake City, to support the development of a new class of antibiotics to treat a broad spectrum of life-threatening gram-negative bacteria that are resistant to currently available antibiotics. Curza’s initial award is worth up to $2.2 million, with the possibility of $1.8 million more if it achieves certain milestones.Kevin Outterson, JD, executive director of CARB-X, said in a statement from the group, “Curza’s new class of antibiotics is an exciting addition to the Powered by CARB-X portfolio as it has been decades since the last new class was approved to for gram-negative bacteria.” Curza’s CZ-02 series is designed to kill bacteria with known resistance to other ribosomal antibiotics by binding to a clinically undrugged and highly conserved site on the bacterial ribosome.The drugs have a unique mechanism that maximizes penetration of bacterial cells that leads to potent activity against drug-resistant ESKAPE pathogens, which include Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species.In another CARB-X development, the group today announced two funding rounds, one open from Mar 22 through Mar 29, targeting new classes of direct-acting small-molecule and large-molecule antibacterials that target certain gram-negative bacteria. The second round is open from Jun 1 through Jun 8 and includes direct-acting therapies and a broader scope of vaccines, drugs, diagnostics, and devices that meet certain criteria.Outterson said, “The scope of each funding cycle has been carefully designed to meet the most urgent needs in the global pipeline to treat drug-resistant bacterial infections and respond to the rising threat of drug resistant bacteria.”Feb 15 CARB-X press release Feb 20 CARB-X press release MRSA bacteremia rates higher in states with more African-AmericansA new analysis of hospital-onset methicillin-resistant Staphylococcus aureus bacteremia (HO-MRSAB) rates suggests that states with more African-American residents have higher incidence, researchers reported yesterday in Infection Control and Hospital Epidemiology.In the study, researchers looked at state-level HO-MRSAB data for the year 2013 obtained from the Centers for Disease Control and Prevention and at census-derived demographic and socioeconomic variables. Although variations in HO-MRSAB rates among states have been explained by differences in the quality of infection-control practices, the researchers wanted to evaluate whether risk factors that have been well-studied at the individual level (including race, age, gender, and diabetic status) affect variations among populations.Univariate analysis demonstrated significant positive correlations between HO-MRSAB rates and poverty rates, income inequality, percent of the population with diabetes, and the percent of the population that self-identify as African-American. But on multivariable analysis, the researchers found that African-American identity was the only variable that retained statistical significance.While acknowledging that the findings suggest only a correlation and require further investigation, the authors of the study say that identifying population-level risk factors for HO-MRSAB is the first step toward developing risk-adjustment tools that would allow for more meaningful comparisons among states and more accurate estimates of the contribution of infection-control practices. Feb 19 Infect Control Hosp Epidemiol abstract FAO warns about antimicrobial resistance in Asia-PacificDiseases originating in animals (called zoonotic diseases) and antimicrobial resistance (AMR) are converging in Asia-Pacific nations and threatening human health, the United Nations Food and Agriculture Organization (FAO) Regional Office for Asia and the Pacific warned today.”We need to take action on AMR now because it affects us all,” Juan Lubroth, DVM, FAO’s chief veterinarian and AMR coordinator, said in an FAO news release. He added that antimicrobial overuse and misuse in humans and animals are resulting in the spread of AMR, which is complicating the treatment of many infectious diseases.”Antibiotics and other antimicrobials are vital to treat sick animals and to protect public health by preventing the spread of disease and by keeping pathogens off our plates,” Lubroth told delegates at the Prince Mahidol Awards Conference in Bangkok, where the theme of this year’s annual conference is AMR and emerging infectious diseases.”Governments have a responsibility to their country and to the global community to step-up and ensure that adequate regulations for antimicrobial use and distribution are in-place and enforced,” said Lubroth, “This responsibility extends to providing incentive programmes and enabling mechanisms to help farmers transition away from an unsustainable dependency on antibiotics.”The FAO is working with Asia-Pacific countries such as Bangladesh, Cambodia, Laos, the Philippines, and Vietnam to develop and implement National Action Plans on AMR to raise awareness, promote good practices and legislation, and boost surveillance. The agency has also developed and piloted the Assessment Tool for Laboratories and Antimicrobial Surveillance Systems (ATLASS) in Cambodia, Indonesia, Laos, Thailand, and Vietnam to help them assess their national AMR surveillance systems and laboratories.Feb 20 FAO regional office news release Study finds anti-parasite drug effect against drug-resistant StaphInvestigators looking at the performance of three anti-parasite drugs against Staphylococcus aureus discovered that one of them, ivermectin, demonstrated potent anti-staphylococcal activity against some Staphylococcus isolates, including one that was resistant to methicillin and cefoxitin, according to a study today in Antimicrobial Resistance & Infection Control.Canadian and Pakistani researchers tested ivermectin, levamisole, and albendazole against 21 S aureus isolates from bovine milk collected in Lahore and Faisalabad, Pakistan.They found that ivermectin but not the other drugs exhibited a potent anti-staphylococcal activity at the concentrations of 6.25 and 12.5 micrograms per milliliter against two isolates. One of those isolates was sensitive to methicillin and cefoxitin, while the other was resistant to the two drugs.The authors conclude, “Our novel findings indicate that ivermectin has an anti-bacterial effect against certain S. aureus isolates. However, to comprehend why ivermectin did not inhibit the growth of all Staphylococci needs further investigation.”Feb 20 Antimicrob Resist Infect Control studylast_img read more

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Japan teenager skis to wakeboard gold

first_imgAKITA – Mero Narita, who helped deliver the athletes’ oath for the World Games 11 days ago, delivered a gold medal Sunday — the final day of competition — when she won the women’s wakeboard event in water skiing.Tokyo lifeguard Masami Yusa then made it a mini-gold rush for the host country by winning the women’s beach flags event in the life saving competition, which brought Japan’s gold medal total to nine. GET THE BEST OF THE JAPAN TIMES Japan also struck gold in the demonstration sport of sumo, winning four of the eight gold medals on offer at Tenno Municipal Gymnasium.Russia topped the final medal standings with 24 gold medals and 44 overall (24-15-5), followed by the United States with 31 (15-8-8) and France with 23 (12-5-6). Japan was seventh with nine gold medals and 25 overall (9-6-10). At Ogata Water Ski Course, Narita ignored the pain of a shoulder separation suffered in July to turn in an energetic routine for 44.30 points and the gold medal ahead of Australia’s Leza Bugden and compatriot Kiyomi Suzuki.“I couldn’t worry whether (my shoulder) hurt or not. I had to get out there and do what I enjoy doing,” the Osaka native said.Domu Narita, however, did not fare as well as his 13-year-old sister, finishing eighth in the men’s wakeboard event, won by Vinh-tung Rodolphe of France. Morgan Krause of South Africe won the silver medal and Fabrizio Bennelli of Italy grabbed the bronze.Also in water skiing, three-time world champion Martin Patrice of France came from behind to win the men’s overall title and Elena Milakova of Russia took the women’s crown.In life saving’s surf events, Yusa edged Spain’s Rosa Gonzalez for the gold medal in women’s beach flags and Japanese compatriot Kozue Fujiwara grabbed the bronze at Iwaki Island Park.“I’m so happy to win a gold medal in the first international meet to be held in Japan,” Yusa said.Japan also got a bronze medal in the men’s beach flags event from Hidenobu Tadano behind Spain’s Sergio Leon and Waleed Damon of South Africa. center_img IN FIVE EASY PIECES WITH TAKE 5last_img read more

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Bruno Fernandes in Portuguese interview – Man United ace on messages…

first_imgFollowing an interview with Manchester United’s website which had big coverage in Portugal, Bruno Fernandes has now had a live chat on Instagram with Portuguese singer Carolina Deslandes. One of the quotes which has been doing the rounds in his home country’s media was the one where he said he’d only wear red if playing for the Red Devils or the national team.Due to his old club Sporting being city rivals of Benfica, the midfielder says he’s received a few harsh messages about it.“I received a lot of comments saying that I don’t have the quality to play for Benfica. But I have colleagues who played for Benfica and left and who say they will never play for Sporting. It’s normal, I created bonds with Sporting that I hadn’t created until now,” said Bruno Fernandes (via Record).“Maybe for the moments and for everything that happened. Also for the people, we went through very difficult things inside and at the same time it was very good. We had a mishap in the middle, what happened at the training centre, it’s no secret that it touched everyone.”Embed from Getty ImagesCarolina Deslandes is a friend both of Bruno and of his wife Ana Pinho, so the player spoke a little about his marriage as well, recalling the early days in school.“She refereed my games at school. Did she favour me? No! She once gave me a yellow card for complaining to the referee. She came from the other side of the field, came to me and gave me a yellow card. This is true.”The couple are about to have their second child, having revealed in March that it’s a boy. And Bruno says he’s even tried to convince his wife of a specific name, but he lost that battle.“He’ll be called Gonçalo,” said Bruno, joking with Portuguese footballer Gonçalo Paciencia (via Nova Gente).“Gonçalo Paciência is getting to know now, first hand. It’s not because of you, Gonçalo, if it were because of you he wouldn’t have this name (laughs).“I wanted Bruninho Júnior but I had few people supporting me in that name. I had to give in.”by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksTrending TodayForge of Empires – Free Online GameIf You Like to Play, this City-Building Game is a Must-Have. No Install.Forge of Empires – Free Online GameUndo聽多多 Hearmore.asia我們現正尋找希望使用市面上最新幾乎隱形的助聽器的香港試用者。限50歲以上*聽多多 Hearmore.asiaUndoHero WarsGetting this Treasure is impossible! Prove us wrong!Hero WarsUndoRaid: Shadow Legends | Free DownloadEven Non-Gamers Are Obsessed With This RPG Game (It’s Worth Installing!)Raid: Shadow Legends | Free DownloadUndoCNN with DBS BankWhat Banks Changed To Help SMEs During Covid-19CNN with DBS BankUndoStanChart by CNBC CatalystIs the Banking Industry Key to Unlocking the Potential of Emerging Markets in Global Trade?StanChart by CNBC CatalystUndoLoans | Search AdsNeed a loan? Search hereLoans | Search AdsUndoCoworking Space | Search AdsThe cost of shared office in Hong Kong might surprise youCoworking Space | Search AdsUndo熱門話題生髮率無敵高!96%的禿頭都獲得改善!←這會不會長太多?熱門話題Undolast_img read more

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